Flavonoids are natural polyphenolic compounds found in a wide variety of fruits and vegetables. A subset of flavonoids known as polymethoxylated flavones (PMF) have been shown to possess especially potent cardio-protective benefits.
Polymethoxylated flavones — flavonoid compounds derived from the peels of oranges, tangerines, and other citrus fruits — are highly methoxylated and contain biologically active molecules with unique metabolic properties.
Two of the most-researched polymethoxylated flavones are nobiletin and tangeretin, which are found at unprecedented levels in PMF-SOURCE®. Research has shown that citrus polymethoxylated flavones, including tangeretin and nobiletin, show hypolipidemic activity and significantly lower total serum and very low-density lipoprotein and LDL cholesterol (Kurowska et al., 2004).
What is tangeretin?
Tangeretin is a flavonoid found in the peel of citrus fruits, including mandarins, tangerines, grapefruits and oranges (Rouseff and Ting, 1979). Tangeretin has the usual flavonoid structure with five methoxyl groups, which increases its hydrophobic character.
What is nobiletin?
Nobiletin is a non-polar polymethoxylated flavone (PMFs) found in the citrus peel of various fruits, such as tangerine. Its chemical structure is similar to tangeretin, containing the typical flavonoid structure and six methoxyl groups (one more than tangeretin).